A new study evaluated the biocompatibility of Anacardic acids (AAs) against oral bacteria, from an antibacterial and anti-collagenolytic perspective, as well as their biocompatibility with marrow stem cells. tooth.
The study was carried out by researchers at the University of Brasilia in Brasilia and was presented during an Interactive Talk presentation during the session “Cariology Research-Microbiology/Biofilm Research IV”.
New way to manage root caries
Two hemi-synthetic saturated cashew nut shell-AA derivatives were selected (LDT11 and LDT409). Bacteriostatic activity was tested against Streptococcus mutans R9 and Veillonella parvula ATCC17745.
‘Potential of anti-collagenolytic agents present in cashew nut shells to reduce collagen degradation in root/dentinal caries.’
The antimicrobial potential against S. mutans biofilms was investigated using the collagen-coated Calgary Biofilm Devices (CFU and Live/Dead Confocal). Collagenases from Clostridium histolyticum, Porphyromonas gingivalis, and mutant S. were used to evaluate anti-collagenolytic activity.
The biocompatibility of both compounds with Human Dental Pulp stromal cells (HDPSCs) was studied in 3 different donors (ethical approval DREC 251121/HA/336). The findings were published in International Association for Dental Research (IADR).
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AA inhibits the growth of S. mutans and V. parvula, as well as partially inhibits bacterial collagenase (>5μg/mL). LDT11 (100μg/mL) inhibits 96% of collagenase activity. AA treatment was associated with an acne cell-like morphology, which was observed after 24 h of treatment.
LDT11 at a concentration of 50 ug/mL had bacteriostatic activity against S. mutans and V. parvula, antibacterial activity against mature S. mutans biofilms as well as anti-collagenase activity against collagenases of bacteria. It is biocompatible with HDPSCs, stimulating cell proliferation and differentiation.
Source: Medindia
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