Why do COVID symptoms flare up in people who don’t take Paxlovid?

occurred in 27 percent of participants after initial symptom improvement and in 10 percent of participants after initial symptom resolution.

Rinki Deo and Manish C. Choudhary from Brigham & Women’s Hospital at Harvard Medical School, USA: “Recovery of viral RNA or relapse of symptoms in the absence of antiretroviral therapy is common, but a combination of viral levels high and recovery of symptoms is rare. wrote in the paper, along with other scientists.


The team studied 568 participants. Anterior nasal swab samples were collected for SARS-CoV-2 RNA testing on days 0-14, 21, and 28. Participants recorded the severity of 13 targeted symptoms daily from day 0 to day 28. Those who resisted the virus were older than those who did not (average 54 vs. 47 years).

Co-author Dr Davey Smith, dean of infectious diseases and global public health at the University of California, San Diego School of Medicine, said: “This happens all the time. , was quoted telling NBC news.

However, 27% was higher than what he expected based on anecdotal evidence, Smith noted.

Anyone who’s had COVID, says Smith, can see symptoms return after they initially go away, and those symptoms may be worse or not as bad as the first bout.

“It’s just a change in the natural course of the infection.”

According to the US Centers for Disease Control and Prevention, There is a potential for symptom recurrence in untreated COVID patients.

“Some short return of symptoms may be part of the natural history of infection with SARS-CoV-2 (the virus that causes COVID-19) in some people, independent of treatment with Paxlovid and regardless of immunization status,” the agency said.

However, The CDC also issued a health alert in May informing doctors about relapses of Paxlovid.

A return of symptoms has been observed more often in people who have taken Paxlovid tablets including nirmatrelvir and ritonavir tablets, which are packaged together for use by mouth. Famous names include US President Joe Biden and chief medical adviser to the White House, Dr. Anthony S. Fauci – both of whom, after receiving negative test results, came back positive in one school. case of “recovery”.

In clinical trials, Paxlovid has been shown to reduce the odds that a person at risk of severe COVID-19 will need to be hospitalized by nearly 90% compared with placebo.

Meanwhile, the CDC issued new guidance last week for people experiencing COVID-19 recovery after Paxlovid.

The CDC says people who test positive again and have symptoms again after taking their antiretroviral medication should begin their full 5-day quarantine and isolation period again.

The agency says people can end their quarantine in five days as long as they have been fever free for 24 hours without fever-reducing medication and they feel better. The agency also recommends that people wear masks for 10 days after their symptoms return.

Source: IANS

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